Productive Infection of Neonatal CD 8 1 T Lymphocytes by HIV - 1
نویسندگان
چکیده
From the * University of Montreal, Centre de Recherche Louis-Charles Simard, Hôpital Notre-Dame, Montreal, Quebec H2L 4M1, Canada; the ‡ Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland 20889; the § Division of Retrovirology, Walter Reed Army Institute for Research, Rockville, Maryland 20850; the i Experimental Immunology Branch, National Institutes of Health, Bethesda, Maryland 20892; the ¶ National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892; the ** Department of Obstetrics/Gynecology and Medicine, Division of Infectious Diseases, Northwestern University Medical School, Chicago, Illinois 60611; and the ‡‡ Hematology-Oncology Division, University of Pennsylvania, Philadelphia, Pennsylvania 19104
منابع مشابه
Productive Infection of Neonatal CD8+ T Lymphocytes by HIV-1
CD8+ T lymphocytes confer significant but ultimately insufficient protection against HIV infection. Here we report that activated neonatal CD8+ T cells can be productively infected in vitro by macrophage-tropic (M-tropic) HIV-1 isolates, which are responsible for disease transmission, whereas they are resistant to T cell-tropic (T-tropic) HIV strains. Physiological activation of CD8-alpha/beta+...
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